The Laboratory of Chemical Epigenetics
The Laboratory of Chemical Epigenetics
Posttranslational modifications (PTMs, e.g. acetylation, phosphorylation, methylation, lipidation) of proteins are involved in the regulation of essentially every cellular process, such as gene expression, signal transduction and metabolism. The LI group is interested in studying regulatory mechanisms and cellular functions of PTMs by combining state-of-the-art chemistry, biochemistry, biophysics and cell biology approaches.
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NEWS
October, 2017
Our research paper entitled “Site-Specific Installation of Succinyl-Lysine Analog into Histones Reveals the Effect of H2BK34 Succinylation on Nucleosome Dynamics” was accepted by Cell Chemical Biology. 
September, 2017
Welcome Yiping Wu to join our group as Ph.D student.
March, 2017
Congratulations Dr. Xiang David Li on winning Outstanding Young Researcher Award!
December, 2016
Our research paper entitled “Histone Ketoamide Adduction by 4-Oxo-2-nonenal Is a Reversible Posttranslational Modification Regulated by Sirt2” was published in ACS Chemical Biology.